NCI TIL cGMP Modular Project
Additional Info
Award Winner : Perkins&Will
Architectural Excellence : The National Cancer Institute (NCI) Tumor-Infiltrating Lymphocytes (TIL’s) production facility is designed and constructed to serve the NCI surgery branch at NIH’s Bethesda campus. The new program for the project involved the design and construction of a Current Good Manufacturing Process (cGMP) modular facility. The new facility provides more ISO controlled space enabling a greater throughput of product. This facility is required to comply more closely with the latest cGMP, CGTP, and Food and Drug Administration (FDA) requirements and regulations. This facility is required to produce reliable TIL doses for safe injection into human subjects in compliance with FDA regulations and requirements. The facility is approximately 14,200 Gross Square Feet (GSF) consisting of ten (10) modular units that house cGMP cell processing labs, lab supporting spaces, storage, as well as the MEP and IT spaces. MEP equipment serving the labs are on top of the module.
Cost Energy Effectiveness : The aseptic facility requires a material that does not allow the growth of any type of microorganism and surfaces that can be easily cleaned. This required fewer joints between the materials exposed in the ISO 7 rooms. The interior wall utilizes a seamless arcoplast wall. The only joints are the four corners of the room and the joint where the wall meets the floor and the ceiling. The flooring is sheet vinyl, and the ceiling is again the same material as the wall. The wall base is an integral cove base. All diffusers and light fixtures are cleanroom rated fixtures.
The exterior of the building is a metal panel with a Kynar metallic finish. The insulated roof is KEE roofing. The main entry vestibule is the only stick-built space with a curtain wall system. The modules were picked up via crane and lowered to the designated piers that supported the modules. The joint between the modules was sealed and the platform was anchored on the top of the module.
Design Firm Name : Perkins&Will
Engineering Firm Name : Genesis Engineering
Occupied Date : 1/4/2021
Production Start Date : 7/2/2018
Project Location City : Bethesda
Project Location State Name : Maryland
Technical Innovation : The civil and the landscape consultants designed three micro bio-retention ponds with native vegetation planted. These micro bio-retention ponds were designed for stormwater management.
To maintain the ISO classification of the room’s airlocks are required. This required doors to be interlocked using mag locks. The ISO 7 and ISO 8 rooms are monitored for temperature and humidity using EMS as well as the equipment in the room are also monitored. The doors are stainless steel and are equipped with wave activation, so no touch is required. Factory Acceptance Test (FAT) for modular and scientific equipment was performed in the manufacturing plant/factory. Subsequent commissioning (Cx), Qualification (IQ, OQ), and Validation support, Construction Quality Management, and project closeout services occurred after the modular units were installed on-site. The building was able to achieve EUI 46% below by using energy-efficient equipment and utilizing energy recovery units.
Total Square Feet : 14200
Category : Permanent: Healthcare: over 10,000 sq. ft.